INVESTIGATION OF THE EFFECT OF COMPOUND B-47/2 CONTAINING AZOMETHINE GROUP ON ANGIOGENESIS

Objective: Lung cancer is one of the most common cancers in world. It known that angiogenesis plays a role development and metastasis lung cancer. The anticancer properties azomethine derivatives as Schiff bases have been demonstrated. In this study, we aimed to determine activity newly synthesized derivative compound B-47/2 on effect component VEGFB gene expression.
 Material Method: Compound was for first time. applied cell line A549 at varying concentrations (1-100 µg/mL) its found after 24, 48 72 incubations using MTT method. IC50 dose cells RNA isolation followed by cDNA synthesis performed. Then, RT-PCR method used expression level VEGF gene.
 Results: As result, it determined A-549 showed highest cytotoxic hours incubation. addition, decreased Discussion: There are studies which has observed. topic synthesizing new drugs prevent popular. We suggested may be effective angiogenesis.